RosettaMHC models of SARS-CoV-2 peptide/HLA-A02 antigens


NetMHCpan-4.0 predictions:

Download top 3 models

(α1 / α2 domains only)
(to navigate: orient the molecule with the straight α-helix toward the top of the screen, then the peptide sequence is read left to right, N- to C-terminus)

Vertical black lines mark the %Rank and Rosetta binding energy of the current peptide. The background distributions are computed across all similar peptides in the set.


  1. Jurtz, V., S. Paul, M. Andreatta, P. Marcatili, B. Peters, and M. Nielsen. 2017. NetMHCpan-4.0: Improved Peptide-MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data. J. Immunol. Baltim. Md 1950 199: 3360–3368.
  2. Nerli, S and Sgourakis, N. G. 2020. Manuscript submitted. (bioRxiv)
  3. Rego, N. and Koes, D. 3Dmol.js: molecular visualization with WebGL. Bioinformatics. 2014 31: 1322-1324