RosettaMHC models of SARS-CoV-2 peptide/HLA-A02 antigens

Epitope:

NetMHCpan-4.0 predictions:

Download top 3 models


(α1 / α2 domains only)
(to navigate: orient the molecule with the straight α-helix toward the top of the screen, then the peptide sequence is read left to right, N- to C-terminus)

Vertical black lines mark the %Rank and Rosetta binding energy of the current peptide. The background distributions are computed across all similar peptides in the set.

References:

  1. Jurtz, V., S. Paul, M. Andreatta, P. Marcatili, B. Peters, and M. Nielsen. 2017. NetMHCpan-4.0: Improved Peptide-MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data. J. Immunol. Baltim. Md 1950 199: 3360–3368.
  2. Nerli, S and Sgourakis, N. G. 2020. Manuscript submitted. (bioRxiv)
  3. Rego, N. and Koes, D. 3Dmol.js: molecular visualization with WebGL. Bioinformatics. 2014 31: 1322-1324